Publications and Preprints

  1. Lundgren SM*, Rocha-Gregg BL*, Akdoğan E, Mysore MN, Hayes S, Collins SR. 2023. Signaling dynamics distinguish high- and low-priority neutrophil chemoattractant receptors. Sci Signal. 2023 Oct 3;16(805):eadd1845. [Epub 2023 Oct 3]  Full Text
  2. Belliveau NM, Footer MJ, Akdoǧan E, van Loon AP, Collins SR, Theriot JA. 2023. Whole-genome screens reveal regulators of differentiation state and context-dependent migration in human neutrophils. Nat Commun. Sep 18;14(1):5770  Full Text
  3. Dreyer CA, VanderVorst K, Natwick D, Bell G, Sood P, Hernandez M, Angelastro JM, Collins SR, Carraway KL 3rd. 2023. A complex of Wnt/planar cell polarity signaling components Vangl1 and Fzd7 drives glioblastoma multiforme malignant properties. Cancer Lett. Jul 28;567:216280.  doi: 10.1016/j.canlet.2023.216280
  4. VanderVorst K, Dreyer CA, Hatakeyama J, Bell GRR, Learn JA, Berg AL, Hernandez M, Lee H, Collins SR, Carraway KL 3rd. 2023. Vangl-dependent Wnt/planar cell polarity signaling mediates collective breast carcinoma motility and distant metastasis. Breast Cancer Res. May 5;25(1):52  Full Text
  5. Hadjitheodorou A, Bell GRR, Ellett F, Irimia D, Tibshirani R, Collins SR, Theriot JA. 2023. Leading edge competition promotes context-dependent responses to receptor inputs to resolve directional dilemmas in neutrophil migration. Cell Systems. Mar 15;14(3):196-209.e6  Full Text
  6. Akahoshi DT, Natwick DE, Yuan W, Lu W, Collins SR, Bevins CL. 2023. Flagella-driven motility is a target of human Paneth cell defensin activity. PLoS Pathog. Feb;19(2):e1011200  Full Text
  7. Badu-Nkansah KA, Sernas D, Natwick DE, Collins SR. 2023. Modeling Subcellular Protein Recruitment Dynamics for Synthetic Biology. Methods Mol Biol. 2553:189-207. doi: 10.1007/978-1-0716-2617-7_10. 
  8. Liou MJ, Miller BM, Litvak Y, Nguyen H, Natwick DE, Savage HP, Rixon JA, Mahan SP, Hiyoshi H, Rogers AWL, Velazquez EM, Butler BP, Collins SR, McSorley SJ, Harshey RM, Byndloss MX, Simon SI, Bäumler AJ. 2022. Host cells subdivide nutrient niches into discrete biogeographical microhabitats for gut microbes. Cell Host Microbe. doi: 10.1016/j.chom.2022.04.012. [Epub ahead of print] Full Text
  9. Brunetti RM, Kockelkoren G, Raghavan P, Bell GRR, Britain D, Puri N, Collins SR, Leonetti MD, Stamou D, Weiner OD. 2022. WASP integrates substrate topology and cell polarity to guide neutrophil migration. J Cell Biol. 221(2): e202104046. Full Text
  10. Hadjitheodorou A., Bell G.R.R., Ellett F., Shastry S., Irimia D., Collins SR, Theriot JA. 2021. Directional reorientation of migrating neutrophils is limited by suppression of receptor input signaling at the cell rear through myosin II activity. Nat Commun 12, 6619  Full Text
  11. Bell G.R.R., Rincón E., Akdoğan E., Collins SR. 2021. Optogenetic control of receptors reveals distinct roles for actin- and Cdc42-dependent negative signals in chemotactic signal processing. Nat Commun 12, 6148 Full Text
  12. Natwick DE, Collins SR. 2021. Optimized iLID Membrane Anchors for Local Optogenetic Protein Recruitment. ACS Synth Biol. Full Text
  13. Bhagwat NR, Owens SN, Ito M, Boinapalli JV, Poa P, Ditzel A, Kopparapu S, Mahalawat M, Davies OR, Collins SR, Johnson JR, Krogan NJ, Hunter N. 2021. SUMO is a pervasive regulator of meiosis. Elife. 10:e57720 doi: 10.7554/eLife.57720. Full Text
  14. Natwick DE, Collins SR. 2020. Decoding GEFs of animated cells. 2020. Nat Chem Biol. 16(8):812-813. PubMed
  15. Tsai TY, Collins SR, Chan CK, Hadjitheodorou A, Lam PY, Lou SS, Yang HW, Jorgensen J, Ellett F, Irimia D, Davidson MW, Fischer RS, Huttenlocher A, Meyer T, Ferrell JE Jr, Theriot JA. 2019. Efficient Front-Rear Coupling in Neutrophil Chemotaxis by Dynamic Myosin II Localization. Dev Cell. 22;49(2):189-205.e6. Full Text
  16. Haney MS, Bohlen CJ, Morgens DW, Ousey JA, Barkal AA, Tsui CK, Ego BK, Levin R, Kamber RA, Collins H, Tucker A, Li A, Vorselen D, Labitigan L, Crane E, Boyle E, Jiang L, Chan J, Rincón E, Greenleaf WJ, Li B, Snyder MP, Weissman IL, Theriot JA, Collins SR, Barres BA, Bassik MC. 2018. Identification of phagocytosis regulators using magnetic genome-wide CRISPR screens. Nat Genet 50(12):1716-1727. PubMed Full Text
  17. Rincón E, Rocha-Gregg BL, Collins SR. 2018. A map of gene expression in neutrophil-like cell lines. BMC Genomics. 19(1):573. PubMed  Full Text
  18. Bell GRR*, Natwick DE*, Collins SR. 2018. Parallel high-resolution imaging of leukocyte chemotaxis under agarose with Rho-family GTPase biosensors. Methods Mol Biol 1821:71-85. PubMed Full Text
  19. Bell GRR, Collins SR. 2018. “Rho”ing a cellular boat with rearward membrane flow. Dev Cell 46(1):1-3. PubMed
  20. Winans AM, Collins SR, Meyer T. 2016. Waves of actin and microtubule polymerization drive microtubule-based transport and neurite growth before single axon formation. Elife 5:e12387 [Epub 2016 Feb 2.] PubMed  Full Text
  21. Yang HW*, Collins SR*, Meyer T. 2016. Locally excitable Cdc42 signals steer cells during chemotaxis. Nat Cell Biol 18(2):191-201. [Epub 2015 Dec 21]. PubMed  Full Text
  22. Collins SR, Yang HW, Bonger KM, Guignet EG, Wandless TJ, Meyer T. 2015. Using light to shape chemical gradients for parallel and automated analysis of chemotaxis. Mol Syst Biol 11(4):804. PubMed  Full Text
  23. Dey G, Jaimovich A, Collins SR, Seki A, Meyer T. 2015. Systematic discovery of human gene function and principles of modular organization through phylogenetic profiling. Cell Rep 10(6):993-1006. [Epub 2015 Feb 12]. PubMed  Full Text
  24. Galic M, Tsai FC, Collins SR, Matis M, Bandara S, Meyer T. 2014. Dynamic recruitment of the curvature-sensitive protein ArhGAP44 to nanoscale membrane deformations limits exploratory filopodia initiation in neurons. Elife 3:e03116. PubMed  Full Text
  25. Martín GM, King DA, Green EM, Garcia-Nieto PE, Alexander R, Collins SR, Krogan NJ, Gozani OP, Morrison AJ. 2014. Set5 and Set1 cooperate to repress gene expression at telomeres and retrotransposons. Epigenetics 9(4):513-22. [Epub 2014 Jan 17]. PubMed  Full Text
  26. Frost A, Elgort MG, Brandman O, Ives C, Collins SR, Miller-Vedam L, Weibezahn J, Hein MY, Poser I, Mann M, Hyman AA, Weissman 2012. Functional repurposing revealed by comparing S. pombe and S. cerevisiae genetic interactions. Cell 149(6):1339-52. PubMed  Full Text
  27. Ryan CJ, Roguev A, Patrick K, Xu J, Jahari H, Tong Z, Beltrao P, Shales M, Qu H, Collins SR, Kliegman JI, Jiang L, Kuo D, Tosti E, Kim HS, Edelmann W, Keogh MC, Greene D, Tang C, Cunningham P, Shokat KM, Cagney G, Svensson JP, Guthrie C, Espenshade PJ, Ideker T, Krogan 2012. Hierarchical modularity and the evolution of genetic interactomes across species. Mol Cell 46(5):691-704. PubMed  Full Text
  28. Hoppins S*, Collins SR*, Cassidy-Stone A, Hummel E, Devay RM, Lackner LL, Westermann B, Schuldiner M, Weissman JS, Nunnari J. 2011. A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria. J Cell Biol 195(2)323-40. PubMed  Full Text
  29. Charles GM, Chen C, Shih SC, Collins SR, Beltrao P, Zhang X, Sharma T, Tan S, Burlingame AL, Krogan NJ, Madhani HD, Narlikar GJ. 2011. Site-specific acetylation mark on an essential chromatin-remodeling complex promotes resistance to replication stress. Proc Natl Acad Sci U S A 108(26):10620-5. PubMed  Full Text
  30. Collins SR, Meyer T. 2011. Evolutionary origins of STIM1 and STIM2 within ancient Ca2+ signaling systems. Trends Cell Biol 21(4):202-11. PubMed  Full Text
  31. Collins SR, Roguev A, Krogan NJ. 2010. Quantitative genetic interaction mapping using the E-MAP approach. Methods Enzymol 470:205-31. PubMed  Full Text
  32. Collins S, Meyer T. 2010. Cell biology: A sensor for calcium uptake. Nature 467(7313):283. PubMed  Full Text
  33. Breslow DK, Collins SR, Bodenmiller B, Aebersold R, Simons K, Shevchenko A, Ejsing CS, Weissman JS. 2010. Orm family proteins mediate sphingolipid homeostasis. Nature 463(7284):1048-53. PubMed  Full Text
  34. Collins SR, Weissman JS, Krogan NJ. 2009. From information to knowledge: new technologies for defining gene function. Nat Methods 6(10):721-23. PubMed  Full Text
  35. Kornmann B, Currie E, Collins SR, Schuldiner M, Nunnari J, Weissman JS, Walter P. 2009 An ER-mitochondria tethering complex revealed by a synthetic biology screen. Science 325(5939):477-81 [Epub 2009 Jun 25]. PubMed  Full Text
  36. Jonikas MC, Collins SR, Denic V, Oh E, Quan EM, Schmid V, Weibezahn J, Schwappach B, Walter P, Weissman JS, Schuldiner M. 2009. Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum. Science 323(5922): 1693-7. PubMed  Full Text
  37. Fiedler D, Braberg H, Mehta M, Chechik G, Cagney G, Mukherjee P, Silva AC, Shales M, Collins SR, van Wageningen S, Kemmeren P, Holstege FC, Weissman JS, Keogh MC, Koller D, Shokat KM, Krogan NJ. 2009. Functional organization of the S. cerevisiae phosphorylation network. Cell 136(5):952-63. PubMed  Full Text
  38. Collins SR, Meyer T. 2009. Calcium flickers lighting the way in chemotaxis? Dev Cell 16(2):160-1. PubMed  Full Text
  39. Wang H, Kakaradov B, Collins SR, Karotki L, Fiedler D, Shales M, Shokat KM, Walther TC, Krogan NJ, Koller D. 2009. A complex-based reconstruction of the Saccharomyces cerevisiae interactome. Mol Cell Proteomics 8(6):1361-81 [Epub 2009 Jan 27]. PubMed  Full Text
  40. Wilmes GM, Bergkessel M, Bandyopadhyay S, Shales M, Braberg H, Cagney G, Collins SR, Whitworth GB, Kress TL, Weissman JS, Ideker T, Guthrie C, Krogan NJ. 2008. A genetic interaction map of RNA-processing factors reveals links between Sem1/Dss1-containing complexes and mRNA export and splicing. Mol Cell 32(5):735-46. PubMed  Full Text
  41. Roguev A, Bandyopadhyay S, Zofall M, Zhang K, Fischer T, Collins SR, Qu H, Shales M, Park HO, Hayles J, Hoe KL, Kim DU, Ideker T, Grewal SI, Weissman JS, Krogan NJ. 2008. Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast. Science 322:405-10. PubMed  Full Text
  42. Typas A, Nichols RJ, Siegele DA, Shales M, Collins SR, Lim B, Braberg H, Yamamoto N, Takeuchi R, Wanner BL, Mori H, Weissman JS, Krogan NJ, Gross CA. 2008. High-throughput, quantitative analyses of genetic interactions in E. coli. Nat Methods 5(9):781-7. PubMed  Full Text
  43. Breslow DK, Cameron DM, Collins SR, Schuldiner M, Stewart-Ornstein J, Newman HW, Braun S, Madhani HD, Krogan NJ, Weissman JS. 2008. A comprehensive strategy enabling high-resolution functional analysis of the yeast genome. Nat Methods 5:711-8. PubMed  Full Text
  44. Feng BY, Toyama BH, Wille H, Colby DW, Collins SR, May BC, Prusiner SB, Weissman J, Shoichet BK. 2008. Small-molecule aggregates inhibit amyloid polymerization. Nat Chem Biol 4:197-9. PubMed  Full Text
  45. Morrison AJ, Kim JA, Person MD, Highland J, Xiao J, Wehr TS, Hensley S, Bao Y, Shen J, Collins SR, Weissman JS, Delrow J, Krogan NJ, Haber JE, Shen X. 2007. Mec1/Tel1 phosphorylation of the INO80 chromatin remodeling complex infuences DNA damage checkpoint responses. Cell 130:499-511. PubMed  Full Text
  46. Ihmels J, Collins SR, Schuldiner M, Krogan NJ, Weissman JS. 2007. Backup without redundancy: genetic interactions reveal the cost of duplicate gene loss. Mol Syst Biol 3:86 [Epub 2007 Mar 27]. PubMed  Full Text
  47. Laribee RN, Shibata Y, Mersman DP, Collins SR, Kemmeren P, Roguev A, Weissman JS, Briggs SD, Krogan NJ, Strahl BD. 2007. CCR4/NOT complex associates with the proteasome and regulates histone methylation. Proc Natl Acad Sci U S A 104(14):5836-41. PubMed  Full Text
  48. Collins SR, Miller KM, Maas NL, Roguev A, Fillingham J, Chu CS, Schuldiner M, Gebbia M, Recht J, Shales M, Ding H, Xu H, Han J, Ingvarsdottir K, Cheng B, Andrews B, Boone C, Berger SL, Hieter P, Zhang Z, Brown GW, Ingles CJ, Emili A, Allis CD, Toczyski DP, Weissman JS, Greenblatt JF, Krogan NJ. 2007. Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map. Nature 446(7137):806-10. PubMed  Full Text
  49. Collins SR*, Kemmeren P*, Zhao X, Greenblatt JF, Spencer F, Holstege FC, Weissman JS, Krogan NJ. 2007. Towards a comprehensive atlas of the physical interactome of Saccharomyces cerevisiae. Mol Cell Proteomics 6(3):439-50. PubMed  Full Text
  50. Schuldiner M*, Collins SR*, Weissman JS, Krogan NJ. 2006. Quantitative genetic analysis in Saccharomyces cerevisiae using epistatic miniarray profiles (E-MAPs) and its application to chromatin functions. Methods 40(4):344-52. PubMed  Full Text
  51. Collins SR, Schuldiner M, Krogan NJ, Weissman JS. 2006. A strategy for extracting and analyzing large-scale quantitative epistatic interaction data. Genome Biol. 7: R63. PubMed  Full Text
  52. Tanaka M, Collins SR, Toyama BH, Weissman JS. 2006. The physical basis of how prion conformations determine strain phenotypes. Nature 442(7102): 585-9. PubMed  Full Text
  53. Krogan NJ, Cagney G, Yu H, Zhong G, Guo X, Ignatchenko A, Li J, Pu S, Datta N, Tikuisis AP, Punna T, Peregrin-Alvarez JM, Shales M, Zhang X, Davey M, Robinson MD, Paccanaro A, Bray JE, Sheung A, Beattie B, Richards DP, Canadien V, Lalev A, Mena F, Wong P, Starostine A, Canete MM, Vlasblom J, Wu S, Orsi C, Collins SR, Chandran S, Haw R, Rilstone JJ, Gandi K, Thompson NJ, Musso G, St Onge P, Ghanny S, Lam MH, Butland G, Altaf-Ul AM, Kanaya S, Shilatifard A, O’Shea E, Weissman JS, Ingles CJ, Hughes TR, Parkinson J, Gerstein M, Wodak SJ, Emili A, Greenblatt JF. 2006. Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature 440(7084): 637-43. PubMed  Full Text
  54. Keogh MC, Kurdistani SK, Morris SA, Ahn SH, Podolny V, Collins SR, Schuldiner M, Chin K, Punna T, Thompson NJ, Boone C, Emili A, Weissman JS, Hughes TR, Strahl BD, Grunstein M, Greenblatt JF, Buratowski S, Krogan NJ. 2005. Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex. Cell 123: 593-605. PubMed  Full Text
  55. Schuldiner M, Collins SR, Thompson NJ, Denic V, Bhamidipati A, Punna T, Ihmels J, Andrews B, Boone C, Greenblatt JF, Weissman JS, Krogan NJ. 2005. Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile. Cell 123: 507-19. PubMed  Full Text
  56. Collins SR, Douglass A, Vale RD, Weissman JS. 2004. Mechanism of prion propagation: amyloid growth occurs by monomer addition. PLoS Biol. 2: e321. PubMed  Full Text
  57. Chien P, DePace AH, Collins SR, Weissman JS. 2003. Generation of prion transmission barriers by mutational control of amyloid conformations. Nature 424: 948-951. PubMed  Full Text


  1. * denotes equal author contributions